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Inventing and improving pace makers - from Sydney to the world (guest post)

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As the body’s primary device for pumping blood over the body, the heart was seen as the most critical organ (after the brain), protect­ed by the rib cage. But even healthy bodies were vulnerable to dis­eases and de­f­ects. Aptly Dutch doc­tor-physiologist Willem Einthoven won the 1924 Nobel Prize in Med­ic­ine for electro­cardiog­raphy.

British-born Mark Lidwill (1878-1968) emigrated with his parents to Aust­ralia in 1894. Lidwill studied medicine at Melb­ourne Uni, grad­uat­ing with honours (1902) and a Doct­or­ate in Med­ic­ine (1905). He in­v­ented unique medical tools & methods, including successfully desig­ning & manufacturing the Lid­will Intra-Tracheal Anaes­thetic Machine (1910), used in Austral­ian operating theatres for 3 decades.

Dr Lidwill designed and patented the Lidwill Anaesthetic machine

Crown St Women's Hospital, Sydney 
now closed  

He moved to Sydney in 1913, becoming an anaesth­et­ics lecturer at Roy­al Prince Alfred Hospital. In 1926 he worked in an­aesth­etics & cardiol­ogy with Sydney Uni phys­ic­ist Edgar Booth at Crown St Women's Hospital, inventing a portable machine for mechanical or insufflation anaesthesia. Dr Lid­will succ­ess­fully re­vived a still­born baby using el­ectrical stim­ul­ation to the heart i.e he pl­aced a needle directly into the baby’s heart, admin­ist­ering 16-volt impulses.

His invention, cardiac pacemaker, has saved many lives and was named by Nat­ional Geographic as being a Top Australian Invention That Chang­ed the World. In order to avoid public con­troversy, Dr Lid­well unfortunately did NOT patent his invention, and he did NOT leave photos of the machine. But he did write a detailed report to 3rd Congress of the Australian Medical Society

Having heard of Dr Lid­well’s success, Dr Albert Hyman (1893-1972) wanted to develop a sim­ilar de­vice in NY­. Hyman learned how to revive a stopped heart with intra-cardiac ther­apy. His plan was to inject drugs like epin­ephrine that caused the heart to move again, but real­is­ed that it was the physical act of inserting the needle that caused card­iac wall action. In 1932, this cardiol­ogist resus­cit­ated some pat­ients using periodic voltage impulses. He built an electro­-mechanical device and then pace­maker-powered by a hand-cranked motor.

Hyman's processes did not win general accept­ance from U.S’s med­ic­al community that wasn’t ready to embrace cardiac electro-stimulat­ion. Their opposit­ion later caused him to turn to the US Navy in WW2, to use his device on military pers­on­nel dying in tents. Fortunately his vision evolved, with fur­ther expert work in Sweden etc.

In the 1950s scientists met the chall­enge of correcting the irreg­ular beats caused by the heart’s natural pacemaker, the sinus node. And the advent of modern advance­ments led scientists and the medical society to imp­rove the qual­ity of pacemakers! The invent­ion of silicon transistors and smal­l­er batteries helped with portability.

In 1951, Canadian electrical engineer John Hopps of the National Re­search Council of Canada/NRC created the first external portable pace­maker that needed to be plugged into power points. Then Toronto Uni’s Wilfred Bigelow and John Call­aghan, together with John Hopps, jointly published their work on heart stimulation.

In 1952 Boston cardiologist Dr Paul Zoll made the first practical ext­er­nal pace­maker. He used the basic circuitry from Canada’s NRC mach­ine, but instead of having the electrodes attached to the heart it­self, the electrodes were att­ached to the patient’s chest. This device wasn’t suitable for long-term use be­cause 1] it could only be used while the patient was in hosp­it­al and 2] electric shocks to the chest skin involved pain. But the pacemaker got better with micro-tech­nology, crediting Zoll as one of the forefathers of modern cl­in­ical cardiac pacing.

In 1957 scientist Earl Bakken, in response to American heart sur­g­eon Dr Wal­ton Lillehei, developed the first wearable transist­or­ised pace­maker. This pro­totype was meant for labor­atory use, but Lil­lehei liked it so much he used it on various patients. In 1958, promp­t­ed by Swedish Dr Åke Sennings, Dr Rune Elmqvist designed the first re­charg­eable, implantable pacemaker. Dr Senning implanted myocardial elect­rodes and a pulse generator with a rechar­geable nickel-cadmium batt­ery. The first fully implanted pacemaker was succ­essfully inst­al­led in 1958. But it was not until later that long-life lith­ium bat­teries developed by Wilson Great­bach maximised pacemakers’ longevity.

Dr Lillehei examined a young patient wearing an external pacemaker
of the type invented by Earl Bakken, 1961.
Saturday Evening Post

Trans-venous catheter pacing was introduced by Dr Seymour Furman in Montefiore Medical Centre in the Bronx in 1958. Here the electrode was passed down a vein to the interior of the heart, permitting the development of intra­cardiac diagnosis of ar­rythmias/abnormal heart rhythms. But fully implantable pace makers were impossible until the sil­icon transistor was develop­ed. In 3 years of that first implant, a pulse generat­or attached to epicar­dial leads was implanted at Royal Melbourne Hosp­it­al. An eng­ineer, with intermittent comp­lete heart block, rec­eiv­ed epicardial leads and an external pulse generat­or. He proposed a simple sensing circuit, designing the first demand pacing system.

By the mid 1960s, physic­ians were in­sert­ing trans-venous leads in the right ven­tricle att­ached to pulse generators implanted in the anterior abdominal wall. An Australian pacemaker company founded in Sydney, Telectron­ics, designed many of the feat­ures of trans-venous leads and pulse generators we now have.

pacemaker before insertion, 2014
Universities Australia

Posteroanterior chest radiograph of a pacemaker 
with normally located leads in the right atrium.

By 1969 the lithium battery-powered device sensed heart rhythms and generated beats accordingly, so it was classified as a demand-pace­maker. But there was a technological challenge; this pacemaker could not activate the heart’s upper chambers. Science re­spond­ed with developments that allowed pacemakers to restore function to the heart’s lower chambers.

From 1970 on, the electron­ics industry replaced merc­ury batteries with lithium-iodine ones & silic­one rubber enclosed crucial pace­maker components. Pace­makers gained prog­ram­mable use, allowing doc­tors to adjust the device to the patient’s clinical needs. Read the Pace Maker Evolution.

Sydney’s Mark Cowley Lidwill Foundation was established in 2007, to promote and support the world-leading scient­if­ic research in cardiac electro­-phys­iology. Thank you Sydney, my alma mater.

Guest blogger: Dr Joe






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